This has been noted elsewhere, and I didn’t get around to watching it until last night, but Yeardley Smith had a small role as the waiting room nurse on Mad Men this week. (Oddly, especially for someone with such pop-culture juice, it hasn’t popped up on her IMDB page yet.) She gets to tell off a guy who’s waiting for his wife to have their first kid. He’s kind of a dick to her, hence the wry smile you see at right.
I think the weirdest Yeardley Smith sighting (on a TV show) I have encountered was seeing her as a pregnant teen on an episode of “Tales from the Darkside.”